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Showing posts from November, 2024

CelluSense #sciencefather #molecularbiologist #biologist #DNASensor #Ce...

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Bio Probe #sciencefather #molecularbiologist #biologist #LungCancer #Dr...

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Electrotherapy #sciencefather #molecularbiologist #biologist #DCtherap...

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Small brain-penetrating molecule offers hope for treating aggressive brain tumors

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  The study found that gliadin acts on specific cellular pathways to selectively kill glioblastoma cells without harming normal cells. Moreover, the compound can penetrate the blood-brain barrier, which highlights its potential as a treatment option for glioblastoma. Background Glioblastoma is one of the most lethal forms of brain cancer and is known for its resistance to standard therapies. Despite significant advances in cancer therapies , currently used immunotherapies and targeted therapies have had minimal success in improving survival rates in glioblastoma. This resistance is believed to stem from several challenges unique to glioblastoma, such as its complex cellular heterogeneity and immune-evasive characteristics. Additionally, crossing the blood-brain barrier to reach tumor cells remains a significant obstacle. Researchers are exploring novel metabolic pathways as potential therapeutic targets. Unlike typical cancer drugs that inhibit cell division, some emergi...

Career prospects in Molecular Biology

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  M olecular biology is emerging as one of the potential Life Science courses, which have wide applications in the healthcare sector. Molecular Biology involves the study of molecular processes that connect microbiology, medicine, physiology, pharmacology, cytogenetics and biochemistry and also play a role in new drug development, pharmacokinetics, biotechnology and genomic studies. Applications of molecular biology in microbiology research includes characterization of microorganisms using polymerase chain reaction, sequencing and characterization of microorganisms based on DNA and RNA availability. The most recent application was seen in the production of DNA and mRNA vaccines against COVID-19. The field has gained importance after the pandemic due to its potential applications in the production of biologicals against contagious and zoonotic diseases, as it facilitates the identification of the genetic makeup of the pathogenic organisms including virulence, pathogenicity, antib...

Artemisinin #sciencefather #molecularbiologist #biologist #Artemisinin #...

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Deep Omics #sciencefather #molecularbiologist #biologist #MultiOmics #C...

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Solving Delays #sciencefather #molecularbiologist #biologist #DelayEquat...

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Prostate Surge #sciencefather #molecularbiologist #biologist #CancerRese...

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Resistin Insights #sciencefather #molecularbiologist #biologist #Resisti...

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Cancer Spheroids #sciencefather #molecularbiologist #biologist #ColonCa...

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Fluorescent Probes #sciencefather #molecularbiologist #biologist #Fluore...

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Tech-Enabled Biology: Pioneering a New Era in Biotechnology

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  The first biotech revolution began 50 years ago when molecular biologists used DNA engineering to introduce a foreign genetic sequence into a bacteria and successfully produce a protein not encoded by the host genome. This revolutionary moment enabled a new era of scientific research that has radically advanced our understanding of how cells function in health and disease . It also opened the door to wholly new classes of therapies (recombinant proteins, monoclonal antibodies, targeted small molecules, gene and cell therapies, and gene editing) that have improved health outcomes for millions of patients. Despite the transformative power of the first biotech revolution, traditional biopharmaceutical drug development paradigms continue to face significant R&D hurdles even after decades of advancement. There is a less than 10% attrition rate of therapies that make it to clinical trials and a roughly 9% success rate from Phase I to FDA approval, significant obstacles to transl...

The Cosmos Teems with Complex Organic Molecules

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  Ten years ago, the European Space Agency’s Rosetta probe pulled up alongside a dusty, icy lump the size of a mountain. The probe would follow its quarry, a comet called 67P/Churyumov- Gerasimenko, for two years as onboard instruments caught and analyzed the dust and gas streaming away from the comet. Scientists sought hints about how our solar system came to be — and about the origin of one class of molecules in particular. Organic molecules — compounds containing carbon — abound on Earth, especially in the bodies of living things. They’re often called the building blocks of life, and for good reason: Carbon atoms can chemically bond to four other atoms and easily form long, stable chains that serve as “carbon backbones” for complex biological molecules. The Rosetta mission and others have shown just how ubiquitous organic molecules are in space, too. “Rosetta really changed the view,” said Nora Hänni (opens a new tab) , a chemist at the University of Bern who has been ana...

Tocilizumab #sciencefather #molecularbiologist #biologist #Tocilizumab #...

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Cas9-PE Power #sciencefather #molecularbiologist #biologist #Cas9PE #gen...

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Genetic Neuroticism #sciencefather #molecularbiologist #biologist #neuro...

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Maize Drought #sciencefather #molecularbiologist #biologist #genomics #...

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Study unveils new molecular switch protecting cells from death

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  Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death. Programmed cell death protects the body against cancer and other diseases . A team of researchers led by Professor Alexander Bartelt from the Institute for Cardiovascular Prevention (IPEK) has decoded a new mechanism by which oxidative stress influences cell death. The researchers hope this discovery will lead to novel approaches for targeting cancer cells and other diseases . Their findings were recently published in the journal  Cell Death & Differentiation . When the lipids in the plasma are attacked, it is referred to as ferroptosis. In a chain reaction, the lipid molecules that make up the membrane are being destroyed and the cell literally dissolves. The team concentrated on the proteasome, which functions as a sort of recycling bin for the cell. Through the operations of the proteasome, old or damaged proteins are broken down and made available to th...

Cancer Susceptibility #sciencefather #molecularbiologist #biologist #ge...

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Cancer Mechanisms #sciencefather #molecularbiologist #biologist #ovarian...

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Silent Spread #sciencefather #molecularbiologist #biologist #cancerscience

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USP2 Breakthrough #sciencefather #molecularbiologist #biologist #ovaria...

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