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Uncovering the molecular drivers of liver cancer

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  Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored. Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and non-viral chronic liver disease (CLD). One liver cancer, hepatocellular carcinoma (HCC), is associated with CLD in about 15–25% of cases. While increasing awareness and screening of cancers has improved the ability to detect liver cancer at earlier stages when it is more effectively treated, cancer prevention is always a primary goal of both healthcare providers and biomedical researchers. The increasing prevalence of CLD with HCC suggests that this underlying condition predisposes liver tissue to cancer development. In order to investigate how healthy liver tissue differs from th...
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Why Vitamin D Deficiency Can Raise Autoimmune Disease Risk

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  The body can naturally produce vitamin D when skin is exposed to sunlight, but this process declines significantly in winter. There also aren't many food sources of vitamin D. But vitamin D is very important to the body. The  vitamin D receptor  can be found in many different tissues, and while the vitamin's roles in bone health and calcium level maintenance are  well known , less is understood about its other functions, such as how it relates to immunity. Several immune cells have vitamin D receptors and gene activity in those cells can be affected by the vitamin. Low levels of vitamin D have also been associated with a variety of autoimmune disorders including inflammatory bowel disease, multiple sclerosis, psoriasis vulgaris, rheumatoid arthritis, and type 1 diabetes. Studies  have also shown  that vitamin D supplements can help lower the risk of autoimmune disease. A new study  reported in  Science Advances  has provided new insights in...
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Cannabis Leaves Molecular Marks on DNA Linked to Psychosis

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  The research also showed the effect of cannabis use on DNA is different in people experiencing their first episode of psychosis compared to users who have never experienced psychosis, suggesting there could be potential for DNA blood tests to help characterise those cannabis users at risk of developing psychosis to inform preventative approaches.  The study was funded by the Medical Research Council, the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC) and the NIHR Exeter BRC. Senior author Marta Di Forti, Professor of Drugs, Genes and Psychosis at King’s IoPPN  said: “With the increasing prevalence of cannabis use and more availability of high potency cannabis, there is a pressing need to better understand its biological impact, particularly on mental health. “Our study is the first to show high potency cannabis leaves a unique signature on DNA related to mechanisms around the immune system and energy production....
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