Pausing” Cell Death Could Be the Key to Longevity

 


Necrosis drives aging and disease by triggering damaging inflammation. Interrupting it may offer new treatments for chronic conditions and improve health in space travel.

Necrosis, a form of uncontrolled cell death, may hold one of the most promising keys to altering the course of human aging, disease, and even space travel, according to a new study by researchers at UCL, the drug discovery company LinkGevity, and the European Space Agency (ESA).

Challenging conventional thinking, the paper draws on evidence from cancer biology, regenerative medicine, kidney disease, and space health to argue that necrosis is not just a final stage of cell death, but a major driver of aging—and a potential target for intervention.

Dr. Keith Siew, an author of the study from UCL Centre for Kidney & Bladder Health, said: “Nobody really likes talking about death, even cell death, which is perhaps why the physiology of death is so poorly understood. And in a way, necrosis is death. If enough cells die, then tissues die, then we die. The question is what would happen if we could pause or stop necrosis.”

Cells are the basic building blocks of life and can die in several different ways. Programmed cell death is a beneficial, tightly regulated process that helps tissues renew themselves and maintain proper function throughout life.

In contrast, unprogrammed cell death, known as necrosis, is an uncontrolled and damaging process that causes tissue breakdown and contributes to overall biological decline.

When this finely tuned balance fails, calcium floods the cell like an electrical short circuit, pushing the cell into chaos. Unlike programmed death, where cells dismantle in an orderly manner, necrosis causes cells to rupture, spilling toxic molecules into surrounding tissues.

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