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Uncovering the molecular drivers of liver cancer

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  Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored. Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and non-viral chronic liver disease (CLD). One liver cancer, hepatocellular carcinoma (HCC), is associated with CLD in about 15–25% of cases. While increasing awareness and screening of cancers has improved the ability to detect liver cancer at earlier stages when it is more effectively treated, cancer prevention is always a primary goal of both healthcare providers and biomedical researchers. The increasing prevalence of CLD with HCC suggests that this underlying condition predisposes liver tissue to cancer development. In order to investigate how healthy liver tissue differs from th...
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How to determine the molecular weight of a monoclonal antibody

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  Protein aggregation typically results from conformational or colloidal instability. Conformational stability is the difference in free energy (ΔG) between folded and unfolded states. While not direct assessments of free energy, melting temperature value (T m ) and aggregation temperature (T Agg ) can be utilized as qualitative measurements of conformational stability. Colloidal stability is calculated by balancing repulsive and attractive intermolecular interactions among protein molecules to sustain the native folded state. Less intermolecular interaction reduces the aggregation propensity. Thus, quantifying the second virial coefficient (B 22 ) is an important screening tool for predicting aggregation propensity. ARGEN ™  is the perfect instrument for assessing quantitative and qualitative characteristics of all classes of biotherapeutics and determining T Agg , B 22 , molecular weight (M w ), alongside differences in weight, average molecular weight (aggregation)...
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Pausing” Cell Death Could Be the Key to Longevity

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