Cells use actin and microtubules as a coordinated scaffold


 A Northwestern Medicine study has shed light on one of the most intricate construction projects in biology: how cells build and coordinate the internal scaffolding needed to create a healthy egg. The research, published in the Journal of Cell Biology, details how two structural cellular systems work together to form developing egg cells.

For an egg cell to form, a group of nurse cells all empty their contents into what will become the egg cell. All organelles and proteins, everything, go to the egg cell," said Wen Lu, Ph.D., research assistant professor of Cell and Developmental Biology and a co-author of the study. "This is a very dramatic process that is foundational to the development of life, yet exactly how this is accomplished has remained unclear."

The study, conducted in Drosophila melanogaster (fruit flies), identifies previously unknown collaboration between actin filaments and microtubules—two key components of the cytoskeleton—during egg development.

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#Cytoskeleton #EggDevelopment #Actin #Microtubules #CellBiology #Oogenesis #CellScaffold #MolecularBiology #DevelopmentalBiology #CellStructure #CytoskeletalDynamics #ReproductiveBiology

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